Shih-Hong Chen, Chien-Hung Shih, Ting-Ling Ke, Zi-Xuan Huang,Kuo-Chin Chen,Chia-Ni Hsiung, Tsung-Hsien Chuang, Li-Kuei Chen, Linyi Chen*. (2024) Long-term exposure to morphine reduces taurine level and promotes metastasis of triple-negative breast cancer. (submitted)

Min-Zong Liang, Jenq-Wei Yang, Hsin Chen, Mei-Yuan Cheng, Linyi Chen*. (2024) Quantitative monitoring of neuronal regeneration by functional assay and wireless neural recording. (submitted)

Ting-Ling Ke and Linyi Chen*. High-level dynein impairs mitochondrial distribution and differentiation of rhabdomyosarcoma cells. (submitted)

Shr-Han Weng, Wen-Ling Liao and Linyi Chen*. The enhancer-promoter-mediated Wnt8a transcription during neurite regrowth of injured cortical neurons. (submitted)

Grace H. Chen, Kee-Chin Sia, Shao-Wen Liu, Ying-Chi Kao, Pei-Ching Yang, Chia-Hsin Ho, Shih-Chen Huang, Peng-Ying Lee, Min-Zong Liang, Linyi Chen, Chieh-Cheng Huang*. (2024) Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair. Biomaterials, in press.

Mei-Yun Cheng, Hsuan-Chen Ho, Jung-Lung Hsu, Yi Wang, Linyi Chen, Ming-Feng Liao, Long-Sun Ro*. (2024) Clinical and Structural Biological Studies of Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines. Diseases 2024, 12, 60. 

Hsin-Kai Tseng, Yung-Yu Su, Po-Jen Lai, Shao-Lun Lo, Hsien-Chein Liu, Linyi Chen,* Chun-Cheng Lin*. (2024) Chemoenzymatic Synthesis of GAA-7 Glycan Analogs and Evaluation of Their Neuritogenic Activities. ACS Chemical Neuroscience 2024 Feb 7;15(3):656-670. doi: 10.1021/acschemneuro.3c00732

Li-Kuei Chen, Shiou-Sheng Chen, Chien-Hung Shih, Zi-Xuan Huang, Linyi Chen and Kuen-Bao Chen. (2023) Ketamine Promoted Breast Cancer Invasion and Metastasis Through Up-regulating Wnt, BMP, and EGFR Signaling. Anticancer Research, December 2023, 43 (12) 5415-5424;  DOI: 10.21873/anticanres.16745

Chen-Chan Hsieh, Chia-Chi Chang, Pei-Ju Hsu, Linyi Chen, B Linju Yen. (2023) Protocol for efficient human MSC chondrogenesis via Wnt antagonism instead of TGF-β. STAR Protocols 4(4):102728, DOI: 10.1016/j.xpro.2023.102728.

Min-Zong Liang, Ting-Hsuan Lu, Linyi Chen*. (2023) Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury. Cell & Bioscience (2023) 13:96.

Chen-Chan Hsieh, B. Linju Yen*, Chia-Chi Chang, Pei-Ju Hsu, Yu-Wei Lee, Men-Luh Yen, Shaw-Fang Yet, Linyi Chen. (2023) Wnt Antagonism with TGFβ removal results in rapid and precise human MSC chondrogenesis via increasing adherens junctional interactions and restricting lineage commitment. iScience, 26(1), 105713.

Hsuan-Wen Lin, Chun-Chao Chen, Ruei-Yu Jhang, Linyi Chen, J. Steven de Belle, Timothy p Tully, Ann-Shyn Chiang. (2022) CREBB repression of protein synthesis in mushroom body gates long-term memory formation in Drosophila. Proceedings of the National Academy of Sciences, 119(50), e2211308119.

Li-Kuei Chen,  Chien-Hung Shih,  Shiou-Sheng Chen,  Zi-Xuan Huang,  Yu-Jung Chang , Linyi Chen,  Tsung-Hsien Chuang  &  Kuen-Bao Chen  (2022) Ketamine promotes breast tumor growth in a mouse breast tumor model involving with high expression of miR-27b-3p and EGFR. Investigational New Drugs, Aug. 2022. DOI: 10.1007/s10637-022-01291-x

Jui-Chih Chang,  Linyi Chen  and Chuang-Rung Chang. (2022) Editorial: Mitochondrial therapy in neurological diseases. Front. Mol. Neurosci. 15:988792. DOI: 10.3389/fnmol.2022.988792

Linyi Chen, Hsin-Yen Cho, Tzu-Hsien Chuang, Ting-Ling Ke, and Sheng-Nan Wu*. (2022) The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of erg-mediated K+ Currents. Biomedicines, 2022, 10, 780.

Min-Zong Liang, Ting-Ling Ke, Linyi Chen*. (2021) Mitochondrial protein PGAM5 emerges as a new regulator in neurological diseases. Frontiers in Molecular Neuroscience, 14:730604.

Chung-Pin Hsieh, Hao Chen, Ming-Huan Chan, Linyi Chen, and Hwei-Hsien Chen. (2020) N,N-dimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice. Toxicology, 446, 152613.

Yu-Jung Chang*, Kuan-Wei Chen, Linyi Chen*. (2020) Mitochondrial ROS1 increases mitochondrial fission and respiration in oral squamous cancer carcinoma. Cancers, 12(10), 2845.

Yen-Chi Tsao#, Yu-Jung Chang#*, Chun-Hsien Wang and Linyi Chen*. (2020) Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone. International Journal of Molecular Sciences, 21, 4387.

Linyi, Chen. Epigenetic Regulation of WNT3A Enhancer, Encyclopedia, 2020, v1, Available online: https://encyclopedia.pub/item/revision/d16669dd7dcc4698449bd24187619e50

Chu-Yuan Chang, Jui-Hung Hung, Joye Li, Ka Shing Fung, Cheng-Fu Kao, Linyi Chen*. (2020) Epigenetic regulation of WNT3A enhancer during regeneration of injured cortical neurons. International Journal of Molecular Sciences, 21(5), 1891.

Yen-Ling Lian, Kuan-Wei Chen, Yu-Ting Chou, Ting-Ling Ke, Bi-Chang Chen, Yu-Chun Lin, Linyi Chen*. (2020) PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells. Journal of Cell Science, 133, jcs.240325. doi: 10.1242/jcs.240325. Published 27 March 2020

Chu-Yuan Chang, Min-Zong Liang, Ching-Chih Wu, Pei-Yuan Huang, Hong-I Chen, Shaw-Fang Yet, Jin-Wu Tsai, Cheng-Fu Kao* and Linyi Chen*. (2020) WNT3A promotes neuronal regeneration upon traumatic brain injury. International Journal of Molecular Sciences, 21(4), 1463.

Yue-Zhi Lee, Huan-Chen Guo, Guan-Hao Zhao, Cheng-Wei Yang, Hsin Yu Chang, Ruey-Bing Yang, Linyi Chen and Shiow-Ju Lee. (2020) Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha. Pharmacological Research, 152, 104581.

Yao-Shen Huang, Ching-Hsiang Fan, Ning Hsu, Nai-Hua Chiu, Chun-Yao Wu, Chu-Yuan Chang, Bing-Huan Wu, Shi-Rong Hong, Ya-Chu Chang, Anthony Yan-Tang Wu, Vanessa Guo, Yueh-Chen Chiang, Wei-Chia Hsu, Linyi Chen, Charles Pin-Kuang Lai, Chih-Kuang Yeh* Yu-Chun Lin*. (2020) Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein. Nano Letters , 20, 2, 1089-1100

Chung-Pin Hsieh, Wei-Tang Chang, Linyi Chen, Hwei-Hsien Chen & Ming-Huan Chan. (2019) Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes. Nutritional Neuroscience, July 22: 1-16.

Chu-Yuan Chang, Min-Zong Liang, and Linyi Chen*. (2019) Current progress of mitochondrial transplantation that promotes neuronal regeneration. Translational Neurodegeneration, 2019, 8:17.

Yi-Ju Wu, Bor-Sheng Ko, Shu-Man Liang, Yi-Jhu Lu, Yee-Jee Jan, Shih-Sheng Jiang, Song-Kun Shyue, Linyi Chen and Jun-Yang Liou. (2019) ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma. Cell Death and Disease, 2019 (10):408.

Ling Chien, Min-Zong Liang, Chu-Yuan Chang, Chen Wang, and Linyi Chen*. (2018) Mitochondrial therapy promotes regeneration of injured hippocampal neurons. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864, 9(B):3001-3012.

Ya-Jean Wang, Chung-Pin Hsieh, Ming-Huan Chan, Tzu-Yi Chan, Linyi Chen, Hwei-Hisen Chen. (2018) Distinct effects of resveratrol on seizures and hyperexcitability induced by NMDA and 4-aminopyridine. Nutritional Neuroscience, Dec;22(12):867-876.

Chien-Hung Shih, Yu-Jung Chang, Wei-Chieh Huang, Te-Hsuan Jang, Hsing-Jien Kung, Wen-Ching Wang, Muh-Hwa Yang, Meng-Chin Lin, Hsin Chiu, Shiu-Feng Huang, Shu-Wei Chou, Emily Chang,Tien-Yu Shieh, Yu-Jen Chen, Lu-Hai Wang*, Linyi Chen*. (2017) EZH2-mediated epigenetic regulation of ROS1 targets CXCL1 and GLI1 to promote invasiveness of oral cancer. Oncogene, 36(47):6542-6554.

Kuan-Wei Chen and Linyi Chen*. (2017) Epigenetic regulation of BDNF gene during development and diseases. International Journal of Molecular Sciences, 18, 571.

Kuan-Wei Chen, Yu-Jung Chang, Chia-Ming Yeh, Yen-Ling Lian, Michael W. Y. Chan, Cheng-Fu Kao, Linyi Chen*. (2017) SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1860 (2), 270-281.

Ya-Jean Wang, Ming-Huan Chan, Linyi Chen, Sheng-Nan Wu, Hwei-Hsien Chen. (2016) Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels. Journal of Biomedical Science, 23:47.

Tim Ting-Chung Yen, Anderson Yang, Wen-Tai Chiu, Kuan-Ying Lu, Lyu-Han Wang, Hui-Chen Wang, Linyi Chen, Wen-Ching Wang, Wenya Huang, Meng-Ru Shen, Ih-Jen Su, and Lily Hui-Ching Wang. (2015) Hepatitis B Virus PreS2-mutant Large Surface Antigen Modulates Store-Operated Calcium Entry and thereby Promotes Chromosome Instability. Oncotarget, 7(17):23346-23360.

Da-Wei Yeh, Yu-Syuan Chen, Chao-Yang Lai, Yi-Ling Liu, Chih-Hao Lu, Jeng-Fan Lo, Linyi Chen, Li-Chung Hsu, Yunping Luo, Rong Xiang and Tsung-Hsien Chuang. (2015) Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells. Cell Death and Differentiation, 23, 841-852.

Ling Chien, Wun-Ke Chen, Szu-Ting Liu, Chuang-Rung Chang, Mou-Chieh Kao, Kuan-Wei Chen, I-Chou Hsiang, Yu-Jen Chen*, and Linyi Chen*. (2015) Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons. Oncotarget, 6(31):30628-30639.

Kuan-Wei Chen, Yu-Jung Chang, and Linyi Chen*. (2015) SH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth. Communicative & Integrative Biology, 8(4), e1044189.

Li-Jing Chen, Li Chuang, Yi-Hsuan Huang, Jing Zhou, Seh Hong Lim, Chih-I Lee, Wei-Wen Lin, Ting-Er Lin, Wei-Li Wang, Linyi Chen, Shu Chien, and Jeng-Jiann Chiu. (2015) MicroRNA Mediation of Endothelial Inflammatory Response to Smooth Muscle Cells and its Inhibition by Atheroprotective Shear Stress. Circulation Research, 116(7):1157-69.

Chien-Jen Chen, Chien-Hung Shih, Yu-Jung Chang, Tian-Neng Li, Lily Hui-Ching Wang, Shao-Jing Hong, and Linyi Chen*. (2015) SH2B1 and IRSp53 promotes the formation of dendrites and dendritic branches. Journal of Biological Chemistry, 290:6010-6021.

Shao-Jing Hong, Szu-Ting Liu, Chien-Jen Chen and Linyi Chen*. (2014) SH2B1 increases the numbers of IRSp53-induced filopodia. Biochimica et Biophysica Acta-General Subjects 1840:3335-3344.

Meng-Ling Wu, Chung-Huang Chen, Yung-Tsang Lin, Yuan-Jyun Jheng, Yen-Chun Ho, Liang-Tung Yang, Linyi Chen, Matthew D Layne and Shaw-Fang Yet. (2014) Divergent signaling pathways cooperatively regulate TGFbeta induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Communication and Signaling, 12:22.

Yi-Chao Hsu, Su-Liang Chen, Ya-Jean Wang, Yun-Hsiang Chen, Dan-Yen Wang, Linyi Chen, Chia-Hsiang Chen, Hwei-Hsien Chen, and Ing-Ming Chiu. (2014) Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Translational Medicine, 3:1-10.

Rajesh Raju, Shyam Mohan Palapetta, Varot K. Sandhya, Apeksha Sahu, Abbas Alipoor, Lavanya Balakrishnan, Jayshree Advani, Bijesh George, K. Ramachandra Kini, Geetha N. Prashanth, H. S. Prakash, T. S. Keshava Prasad, Yu-Jung Chang, Linyi Chen, Akhilesh Pandey, H. C. Harsha. (2014) A network map of FGF-1/FGFR signaling system. Journal of Signal Transduction, volume 2014, article ID 962962.

Yu-Jung Chang, Kuan-Wei Chen, Ching-Jen Chen, Ming-Hsing Lin, Yuh-Ju Sun, Jia-Lin Lee, Ing-Ming Chiu, and Linyi Chen*. (2014) SH2B1b interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. Molecular and Cellular Biology, 34(6): 1003-1019.

Chien-Hung Shih, Chien-Jen Chen, and Linyi Chen*. (2013) New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth. PLoS ONE 8(11): e79619.

Yu-Jung Chang, Che-Ming Hsu, Chia-Hua Lin, Michael Shiang-Cheng Lu and Linyi Chen*. (2013) Electrical stimulation promotes nerve growth factor-induced neurite outgrowth and signaling. Biochimica et Biophysica Acta-General Subjects 1830(8):4130-4136.

Yi-Wen Chen, Hsiu-Chuan Chou, Szu-Ting Lin, You-Hsuan Chen, Yu-Jung Chang, Linyi Chen, and Hong-Lin Chan. (2013) Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine 2013: 364519.

Ching-Yu Lin, Chieh Huo, Li-Kuo Kuo, Richard A. Hiipakka, Richard Baker Jones, Hui-Ping Lin, Yuwen Hung, Liang-Cheng Su, Jen-Chih Tseng, Ying-Yu Kuo, Yu-Ling Wang, Yasuhisa Fukui, Yung-Hsi Kao, John M. Kokontis, Chien-Chih Yeh, Linyi Chen, Shiaw-Der Yang, Hsiao-Hui Fu, Ya-Wen Chen, Kelvin K.-C. Tsai, Jang-Yang Chang, Chih-Pin Chuu. (2013) Cholestane-3beta, 5alphs, 6alpha-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells. PLoS ONE, 8(6): e65734.

Hung-Ju Shih, Hsiao-Huei Chen, Yen-An Chen, Meng-Hsun Wu, Gan-Guang Liou, Wei-Wen Chang, Linyi Chen, Lu-Hai Wang, Hsin-Ling Hsu. (2012) Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity.  Oncotarget 3, 1401-1415.

Chia-Ling Wu, Yu-Han Chou, Yu-Jung Chang, Nan-Yuan Teng, Hsin-Ling Hsu, and Linyi Chen* (2012) Interplay between cell migration and neurite outgrowth determines SH2B1b-enhanced neurite regeneration of differentiated PC12 cells. PLoS ONE, 7(4): e34999. Highlighted in the Target Intelligence Service.  

Yu-Tsung Shih, Mei-Cun Wang, Hsin-Hsin Peng, Ting-Fang Chen, Linyi Chen, Jang-Yang Chang, Jeng-Jiann Chiu (2012) Modulation of chemotactic and pro-inflammatory activities of endothelial progenitor cells by hepatocellular carcinoma. Cellular Signalling, 24: 779-793.

Tien-Cheng Wang, Hsun Chiu, Yu-Jung Chang, Tai-Yu Hsu, Ing-Ming Chiu, Linyi Chen* (2011) The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons. PLoS ONE, 6(10): e26433.

Chia-Lin Wu, Meng-Fu Maxwell Shih, Jason Sih-Yu Lai, Hsun-Ti Yang, Glenn C. Turner, Linyi Chen, Ann-Shyn Chiang. (2011) Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Current Biology, 21(10), 845-854. (Selected by Faculty 1000 as top 2% paper of the year.)

Tien-Cheng Wang, Yi-Hsuan Li, Kuan-Wei Chen, Ching-Jen Chen, Chia-Ling Wu, Nan-Yuan Teng and Linyi Chen*. (2011) SH2B1b regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation. Journal of Cellular Physiology, 226: 2063-2074. Selected in “Highlights” of the issue.

Wan-Chen Lu, Chien-Jen Chen, Hui-Chien Hsu, Hsin-Ling Hsu, and Linyi Chen*. (2010) The adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons. Journal of Molecular Signaling 5: 17.

Ravi Kasiappan, Hung-Ju Shih, Meng-Hsun Wu, ChikOn Choy, Tai-Du Lin, Linyi Chen and Hsin-Ling Hsu (2010) The antagonism between MCT-1 and p53 affects the tumorigenic outcomes. Molecular Cancer 9:311.

Wei-Fan Lin, Chien-Jen Chen, Yu-Jung Chang, Su-Liang Chen, Ing-Ming Chiu, Linyi Chen*. (2009) SH2B1b enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.  Cellular Signalling 21:1060-1072.

Travis J. Maures, Linyi Chen, and Christin Carter-Su. (2009) Nucleocytoplasmic shuttling of the adaptor protein SH2B1b (SH2-Bb) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes.  Molecular Endocrinology 23(7):1077-91.

Linyi Chen, Travis J. Maures, Hui Jin, Jeffrey S. Huo, Shafaat A. Rabbani, Jessica Schwartz, and Christin Carter-Su. (2008) SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes   important for neuronal differentiation including genes encoding urokinase plaminogen activator receptor and matrix metalloproteinase 3/10.  Molecular Endocrinology 22(2):454-476.

Hui Li, Wei-Heng Shih, Wan Y Shih, Linyi Chen, S-Ja Tseng and Shiue-Cheng Tang (2008) Transfection of aqueous CdS quantum dots using polyethylenimine. Nanotechnology 19: 475101- 475108.

Linyi Chen and Christin Carter-Su. (2004) Adaptor protein SH2-Bb undergoes nucleocytoplasmic shuttling: Implications for Nerve Growth Factor induction of neuronal differentiation.  Molecular and Cellular Biology 24(9): 3633-3647.

Xiaohong Wang#, Linyi Chen#, Travis J. Maures#, James Herrington and Christin Carter-Su. (2004) SH2-Bb is a positive regulator of NGF-mediated activation of the Akt and the Forkhead family pathway in PC12 cells.  Journal of Biological Chemistry 279(1): 133-141.  (# These authors contribute equally.)

Beimeng Sun, Linyi Chen, Wei Cao, Amy F. Roth, Nicholas G. Davis. (2004) The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXF adaptin sorting signal.  Molecular Biology of the Cell 15: 1397-1406.

György Sipos, Jason H. Brickner, E.J. Brace, Linyi Chen, Alain Rambourg, Francois Kepes, and Robert S. Fuller. (2004) Soi3/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of TGN transmembrane proteins.  Molecular Biology of the Cell 15(7): 3196-3209.

Linyi Chen and Nicholas G. Davis. (2002) Ubiquitin-independent entry into the yeast recycling pathway. Traffic 3(2): 110-23.

Amy F. Roth, Ying Feng, Linyi Chen, Nicholas G. Davis (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase.  Journal of Cell Biology 159(1): 23-28.

Linyi Chen and Nicholas G. Davis. (2000) Recycling of the Yeast a-Factor Receptor.  Journal of Cell Biology 151(3): 731-738. DOI: 10.1083/jcb.151.3.731

Shih-Ching Yang, Jin-Guo Lin, Chiuan-Chian Chiou, Lin-Yi Chen and Jia-Ling Yang. (1994) Mutation specificity of 8-methoxypsoralen plus two doses of UVA irradiation in the HPRT gene in diploid human fibroblasts.  Carcinogenesis 15(2): 201-207.